The epidermal growth factor receptor (EGFR is a tumor resistance biomarker which plays an essential role in the differentiation and proliferation upon activation through the binding of one of its ligands. A non-ligand-binding member of EGFR family, HER2 exerts its activity through heterodimerisation along with its other family members. HER2 is a transmembrane growth factor receptor present in the normal and malignant breast epithelial cells. The phosphorylation of the intracellular tyrosine kinase activates intracellular signaling, thereby, leading to the activation of genes responsible for cellular growth.

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